NO-insensitive sGCbeta1 H105F knockin mice: if NO has no place to go
نویسندگان
چکیده
Address: 1Department of Molecular Biomedical Biology, Faculty of Sciences, Ghent University, Gent, Belgium, 2Department of Molecular Biomedical Research, Molecular Pathology and Experimental Therapy Unit, VIB, Gent-Zwijnaarde, Belgium, 3Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, USA, 4Department of General Physiology and Human Physiology and Pathophysiology, Ghent University, Gent, Belgium and 5Cardiovascular Research, Bayer Schering Pharma AG, Aprather Weg 18a, 42096 Wuppertal, Germany
منابع مشابه
Interstitial cells of Cajal are innervated by nitrergic nerves and express nitric oxide-sensitive guanylate cyclase in the guinea-pig gastrointestinal tract.
Nitric oxide (NO) is a major signaling molecule in the gastrointestinal tract, and released NO inhibits muscular contraction. The actions of NO are mediated by stimulation of soluble guanylate cyclase (sGC, NO-sensitive GC) and a subsequent increase in cGMP concentration. To elucidate NO targets in the gastrointestinal musculature, we investigated the immunohistochemical localization of the bet...
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Extract: Leave me alone, I want to sleep, thanks, I don’t go to group meeting soon, what I said hadn't any importance for others, "No I don’t want to go to occupational therapy", I can't do any work and if make any things its vain probably, picnic? No I'm so tired and prefer to be here and watch the TV". Psychiatric wards nurses faced to these responses when they invite their patients to partic...
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